Absolutely serious and competent in nutritional supplements

Colestin

The lifestyles that modern society imposes on us (a diet rich in saturated fats, reduced physical activity, etc.) very often lead to metabolic alterations that result in pathological forms of cholesterolemia with the consequent onset of possible damage at the level of cardiovascular system.


What is Colestin?
Colestin is a dietary supplement based on Monacolin K (vegetable statin), plant sterols, green tea, coenzyme Q10 and folic acid useful in counteracting cholesterolemia and the oxidative stress associated with it, which is responsible for damage to the arteries. Monacolin K, obtained from fermented red rice (Monascus Purpureus) intervenes in the hepatic synthesis of cholesterol by inhibiting the enzyme HMG-CoA reductase. 

Phytosterols are bioactive components of plants, present in different foods of plant origin. They interfere with the transport of cholesterol in the micelles at the intestinal level, reducing the possibility that dietary cholesterol is absorbed through the transporters assigned to its internalization. The beneficial effect is obtained with a daily intake of at least 0.8g of plant sterols / stanols.

 

Green Tea, rich in polyphenols, has an antioxidant action. Tea consumption has been associated with a reduced cardiovascular risk (1). Randomized controlled trials have indicated that consumption of tea extracts has a positive effect on circulating lipoprotein levels. Treatment with green tea catechins modulates the activity of key enzymes in endogenous cholesterol synthesis such as HMG CoA reductase. Furthermore, it was indicated that the treatment leads to a reduction in the total levels of circulating serum cholesterol associated with an increase in HDL cholesterol levels and a reduction in the levels of oxidized LDL at the endothelial level (2).

 

Coenzyme Q10 is a powerful antioxidant synthesized in the liver like cholesterol. Despite the presence of endogenous antioxidants in the body, it is essential to integrate coenzyme Q10 in therapy with monacolin K, since reducing the synthesis of cholesterol also reduces the synthesis of coenzyme Q10.

Folic acid allows the reduction of plasma homocysteine levels, a metabolite with action damaging to the vasal endothelium.


Ingredients

 

Phytosterols (44.4%); Bulking agent: dicalcium phosphate; Green tea (Camellia sinensis (L.) Kuntze) leaves d.e. tit. * 30% epigallocatechingallate (EGCG), 65% catechins, 95% polyphenols tot. 2; Red Rice (Oryza sativa L., seeds) fermented with Monascus purpureus tit. 4.8-5% total monacolins; Anti-caking agents: silicon dioxide, magnesium salts of fatty acids; Coenzyme Q10; Folic acid (Pteroyl-monoglutamic acid).
* e.s. tit .: titrated dry extract.


Allergens
GLUTEN FREE, WITHOUT LACTOSE.

 

Method of use:
It is recommended to take 1 tablet a day, preferably after dinner or according to medical advice.


Warnings:
Food supplements are not intended as a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of the reach of children under 3 years of age. Do not take in case of hypersensitivity or allergies to one or more components. Do not take a daily amount of 3 mg or more of monacolins from fermented red rice. The product should not be consumed by pregnant or lactating women, children under the age of 18 and adults over the age of 70. Seek medical advice on the consumption of this product if you have any health problems. Do not take the product in case of therapy with lipid-lowering drugs. Do not take the product if you are already taking other products containing fermented red rice. In case of treatment with lipid-lowering drugs, consult your doctor before taking the product. The product is not intended for people who do not need to control the level of cholesterol in the blood; patients undergoing cholesterol-lowering treatment should only consume the product under medical supervision; the product may be nutritionally inadequate for pregnant women, breastfeeding women and children under the age of five; its intake should be provided as part of a varied and balanced diet, which involves the regular consumption of fruit and vegetables in order to help maintain the levels of carotenoids; the consumption of more than 3 g / day of added plant sterols should be avoided; one tablet contains 0.4 g of plant sterols.

 

Preservation rules

Store in a cool, dry place at a temperature not exceeding 25 °C, away from light and / or heat sources.

The minimum storage term refers to the product properly stored in unopened package.

 

Packaging

Pack of 30 tablets.

Download the research texts produced in collaboration with the University of Bologna

-Monacolina K

-Phytosterols

-Green tea


Bibliography

 

1. Bhardwaj P1, Khanna D. Green tea catechins: defensive role in cardiovascular disorders. Chin J Nat Med. 2013;11:345-53.

2. Yang TTC, Koo MWL. Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci 2000;66:411–423.

3. Gylling, H., Radhakrishnan, R., Miettinen, T.A. 1997. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol. Circulation 96 (12), 4226-4231.

4. Nissinen, M., Gylling, H., Vuoristo, M., Miettinen, T.A. 2002. Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am J Physiol Gastrointest Liver Physiol 282 (6), G1009-1015.

5. Ostlund, R.E., Jr., McGill, J.B., Zeng, C.M., Covey, D.F., Stearns, J., Stenson, W.F., Spilburg, C.A. 2002.

6. Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab 282 (4), E911-916.

7. Piironen, V., Lampi, A.M. (2004). Occurrence and levels of phytosterols in foods. New York USA.

8. Valsta, L.M., Lemstrom, A., Ovaskainen, M.L., Lampi, A.M., Toivo, J., Korhonen, T., Piironen, V. 2004. Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake. Br J Nutr 92 (4), 671-678.

9. Cicero, A.F., Derosa, G., Borghi, C. 2010. Red yeast rice and statin-intolerant patients. Am J Cardiol 105 (10), 1504.

10. Cicero, A.F., Derosa, G., Parini, A., Maffioli, P., D'Addato, S., Reggi, A., Giovannini, M., Borghi, C. 2013. Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects. Nutr Res 33 (8), 622-628.

11. Guarneri, M., Mercado, N., Suhar, C. 2009. Integrative approaches for cardiovascular disease. Nutr Clin Pract 24 (6), 701-708.

12. Heber, D., Yip, I., Ashley, J.M., Elashoff, D.A., Elashoff, R.M., Go, V.L. 1999. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 69 (2), 231-236.

 

 

 
Whatsapp